3 resultados para CHD Prediction, Blood Serum Data Chemometrics Methods

em DRUM (Digital Repository at the University of Maryland)


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An inference task in one in which some known set of information is used to produce an estimate about an unknown quantity. Existing theories of how humans make inferences include specialized heuristics that allow people to make these inferences in familiar environments quickly and without unnecessarily complex computation. Specialized heuristic processing may be unnecessary, however; other research suggests that the same patterns in judgment can be explained by existing patterns in encoding and retrieving memories. This dissertation compares and attempts to reconcile three alternate explanations of human inference. After justifying three hierarchical Bayesian version of existing inference models, the three models are com- pared on simulated, observed, and experimental data. The results suggest that the three models capture different patterns in human behavior but, based on posterior prediction using laboratory data, potentially ignore important determinants of the decision process.

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This thesis presents measurements of wall heat flux and flow structure in a canonical film cooling configuration with Mach 2.3 core flow in which the coolant is injected parallel to the wall through a two-dimensional louver. Four operating conditions are investigated: no film (i.e. flow over a rearward-facing step), subsonic film, pressure-matched film, and supersonic film. The overall objective is to provide a set of experimental data with well characterized boundary conditions that can be used for code validation. The results are compared to RANS and LES simulations which overpredict heat transfer in the subsonic film cases and underpredict heat transfer in supersonic cases after film breakdown. The thesis also describes a number of improvements that were made to the experimental facility including new Schlieren optics, a better film heater, more data at more locations, and a verification of the heat flux measurement hardware and data reduction methods.

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Observational studies demonstrate strong associations between deficient serum vitamin D (25(OH)D) levels and cardiovascular disease. To further examine the association between vitamin D and hypertension (HTN), data from the 2003-2006 National Health and Nutrition Examination Survey were analyzed to assess whether the association between vitamin D and HTN varies by sufficiency of key co-nutrients necessary for metabolic vitamin D reactions to occur. Logistic regression results demonstrate independent effect modification by calcium, magnesium, and vitamin A on the association between vitamin D and HTN. Among non-pregnant adults with adequate renal function, those with low levels of calcium, magnesium, and vitamin D levels had 1.75 times the odds of HTN compared to those with sufficient vitamin D levels (p = <0.0001). Additionally, participants with low levels of calcium, magnesium, vitamin A, and vitamin D had 5.43 times the odds of HTN compared to those with vitamin D sufficiency (p = 0.0103).